![]() ![]() The ICER at 90 days was $13,333 per QALY and became negative (“dominated”) relative to the control group within one year and onwards. The savings proved to be incremental over time, increasing to 3.7% over an extrapolated 10 years. Results: In all scenarios, i-FACTOR reduced costs within the first year by 1.4% to 2.1%. Cost-effectiveness was expressed as an incremental cost-effectiveness ratio (ICER). Health-related utility outcome was expressed in quality-adjusted life years (QALYs). In the base-case analysis, both health and societal system costs were evaluated. Two primary outcome measures were assessed: cost and utility. We analyzed various real-world scenarios, including inpatient and outpatient surgical settings as well as private versus public insurances. ![]() Patients randomly received either autograft (N = 154) or i-Factor (N = 165). Methods: The patient cohort was extracted from a prospective, multicenter randomized control trial (RCT) from twenty-two North American centers. To evaluate the cost-effectiveness of i-FACTOR compared to autograft for patients undergoing ACDF surgery. Cost-effectiveness of these innovations remains an often-overlooked aspect of this effort. Objective: The efficacy and safety of traditional anterior cervical discectomy and fusion (ACDF) surgery has improved with the introduction of new implants and compounds. Study Design: We conducted decision analytical modeling using a Markov model to determine the ICER of i-factor compared to autograft in ACDF surgery. Neuronomics LLC, 7320 Woodlake Ave, Suite 215, West Hills, CA, 91307, USA In addition, integrated product teams, at their core, must be adaptable enough to be able to meet changing dynamics and unexpected issues or problems that may arise throughout the course of product development.Bart Thaci, 1 Randy Yee, 2 Kee Kim, 1 Amir Vokshoor, 2– 4 J Patrick Johnson, 5 Jared Ament 2– 5ġUniversity of California, Davis, Sacramento, CA, USA 2Neuronomics LLC, Los Angeles, CA, USA 3Neurosurgery & Spine Group, Los Angeles, CA, USA 4Institute of Neuro Innovation, Santa Monica, CA, USA 5Cedars Sinai Medical Center, Los Angeles, CA, USA The key to creating great integrated product teams is to be able to unify core product development processes that can be tied together to create transparency, and open the lines of communication between all stakeholders involved.
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